If you’re caught in a firefight (don’t worry, you are.) your enemies aren’t going to wait for you to pop a pill. A relapse occurs every 40 minutes or so real time, at which point it’s time to take your meds. The game-mechanic of Malaria is typical of the way that diseases are managed with pharmaceutics: you’re usually asymptomatic (or lightly symptomatic - you certainly can’t run very far without getting winded) so long as you take your meds.
Spoiler Warning: Some details of the Far Cry 2 late game are discussed.
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